Difference between revisions of "McsB"
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| − | * '''Description:''' protein arginine kinase | + | * '''Description:''' protein arginine kinase, modulator of [[CtsR]]-dependent repression <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' targets non-functional CtsR for degradation by [[ClpP]]/[[ClpC]] {{PubMed|20852588}} |
| + | |||
* '''Protein family:''' ATP:guanido phosphotransferase family (according to Swiss-Prot) | * '''Protein family:''' ATP:guanido phosphotransferase family (according to Swiss-Prot) | ||
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* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' | + | * '''Modification:''' autophosphorylation {{PubMed|20852588}}, dephosphorylation by [[YwlE]] {{PubMed|20852588}} |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[McsA]]-[[McsB]]-[[CtsR]], [[McsB]]-[[CtsR]], | + | * '''Interactions:''' |
| + | ** [[McsA]]-[[McsB]]-[[CtsR]], [[McsB]]-[[CtsR]] {{PubMed|20852588}}, [[McsA]]-[[McsB]] | ||
| + | ** [[McsB]]-[[YwlE]] {{PubMed|20852588}} | ||
| + | ** [[McsB]]-[[ClpP]]/[[ClpC]] (rapid degradation of non-phosphorylated McsB) {{PubMed|20852588}} | ||
* '''Localization:''' | * '''Localization:''' | ||
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<pubmed> 19609260 </pubmed> | <pubmed> 19609260 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>17380125,16163393,,17380125,11179229,9987115,8793870,16163393,16497325,19226326,,9987115, 19498169 ,11544224, </pubmed> | + | <pubmed>17380125,16163393,,17380125,11179229,9987115,8793870,16163393,16497325,19226326,,9987115, 19498169 ,11544224, 20852588 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:56, 26 October 2010
- Description: protein arginine kinase, modulator of CtsR-dependent repression
| Gene name | mcsB |
| Synonyms | yacI |
| Essential | no |
| Product | protein arginine kinase |
| Function | control of CtsR activity |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 40 kDa, 5.068 |
| Gene length, protein length | 1089 bp, 363 aa |
| Immediate neighbours | mcsA, clpC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU00850
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: targets non-functional CtsR for degradation by ClpP/ClpC PubMed
- Protein family: ATP:guanido phosphotransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P37570
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260]
[WorldCat.org]
[DOI]
(I p)
Original Publications
