Difference between revisions of "MccA"

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* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[CymR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16513748 PubMed]
 
** [[CymR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16513748 PubMed]
** [[Spx]]: transcription activation {{PubMed|12642660}}
+
** [[Spx]]: transcription activation {{PubMed|12642660,16885442}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
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=References=
 
=References=
  
<pubmed>17056751,16513748,, 12642660, </pubmed>
+
<pubmed>17056751,16513748,16885442, 12642660, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 17:00, 8 October 2010

  • Description: O-acetylserine-thiol-lyase

Gene name mccA
Synonyms yrhA
Essential no
Product O-acetylserine-thiol-lyase
Function methionine-to-cysteine conversion
Metabolic function and regulation of this protein in SubtiPathways:
Cys, Met & Sulfate assimilation
MW, pI 32 kDa, 5.227
Gene length, protein length 921 bp, 307 aa
Immediate neighbours mccB, mtnN
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YrhA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU27260

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: O(3)-acetyl-L-serine + L-homocysteine = L-cystathionine + acetate (according to Swiss-Prot)
  • Protein family: cysteine synthase/cystathionine beta-synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of cysteine (CymR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References