Difference between revisions of "YlmB"

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* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** repressed by thiamine ([[Thi-box]]) {{PubMed|12376536}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[Thi-box]]: [[RNA switch]] {{PubMed|12376536}}
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  
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=References=
 
=References=
  
<pubmed>17618314,, </pubmed>
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<pubmed>17618314,12376536, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:01, 12 June 2010

  • Description: N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase



Gene name ylmB
Synonyms
Essential no
Product N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase
Function thiamine salvage
Metabolic function and regulation of this protein in SubtiPathways:
Thiamin
MW, pI 47 kDa, 4.981
Gene length, protein length 1278 bp, 426 aa
Immediate neighbours ylmA, ylmC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YlmB context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU15350

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine + H2O = formate + 4-amino-5-aminomethyl-2-methylpyrimidine (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s): YodQ

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):Binds 2 zinc or cobalt ions per subunit (according to Swiss-Prot)
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Amy Haas Jenkins, Ghislain Schyns, Sébastien Potot, Guangxing Sun, Tadhg P Begley
A new thiamin salvage pathway.
Nat Chem Biol: 2007, 3(8);492-7
[PubMed:17618314] [WorldCat.org] [DOI] (P p)

Dmitry A Rodionov, Alexey G Vitreschak, Andrey A Mironov, Mikhail S Gelfand
Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms.
J Biol Chem: 2002, 277(50);48949-59
[PubMed:12376536] [WorldCat.org] [DOI] (P p)