BcrC

• Description: undecaprenyl pyrophosphate phosphatase, bacitracin resistance
  
  

Gene name	bcrC
Synonyms	ywoA
Essential	no
Product	undecaprenyl pyrophosphate phosphatase
Function	resistance to bacitracin and oxidative stress
MW, pI	21 kDa, 9.455
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	nrgB, ywnJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU36530

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bcrC/ybjG/ywoA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P94571

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: bcrC

• Sigma factor: SigM PubMed, SigI PubMed, SigW PubMed, SigX PubMed

• Regulation:
  • expression activated by glucose (3.3 fold) PubMed
  • induced by heat shock (SigI) PubMed
  • induced by bacitracin
  • induced by oxidative stress

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Remi Bernard, Pascale Joseph, Annick Guiseppi, Marc Chippaux, François Denizot
YtsCD and YwoA, two independent systems that confer bacitracin resistance to Bacillus subtilis.
FEMS Microbiol Lett: 2003, 228(1);93-7
[PubMed:14612242] [WorldCat.org] [DOI] (P p)