Difference between revisions of "SlrR"
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| − | * '''Description:''' transcriptional activator of competence development and sporulation genes, represses [[SigD]]-dependent flagellar genes, antagonist of [[SlrA]] <br/><br/> | + | * '''Description:''' transcriptional activator of competence development and sporulation genes, represses [[SigD]]-dependent flagellar genes, antagonist of [[SlrA]] and [[SinR]]<br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 12: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || transcription regulator, [[SlrA]] antagonist | |style="background:#ABCDEF;" align="center"| '''Product''' || transcription regulator, [[SlrA]] antagonist | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of initiation of biofilm formation | + | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of initiation of biofilm formation and of autolysis |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm]''' | ||
| Line 54: | Line 54: | ||
=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' binding and concomintant inactivation of [[SlrA]] results in release of [[SinR]] from the [[SinR]]-[[SrlA]] complex and subsequent induction of [[SinR]]-controlled genes and operons for biofilm formation {{PubMed|19788541}} | + | * '''Catalyzed reaction/ biological activity:''' binding and concomintant inactivation of [[SlrA]] results in release of [[SinR]] from the [[SinR]]-[[SrlA]] complex and subsequent induction of [[SinR]]-controlled genes and operons for biofilm formation {{PubMed|19788541}}, repression of transcription of ''[[lytA]]-[[lytB]]-[[lytC]]'' and ''[[lytF]]'' {{PubMed|20351052}} |
* '''Protein family:''' | * '''Protein family:''' | ||
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* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' interaction with [[SinR]] triggers binding of SlrR to the promoters of ''[[lytA]]-[[lytB]]-[[lytC]]'' and ''[[lytF]]'', resulting in their repression {{PubMed|20351052}} |
* '''Interactions:''' [[SlrA]]-[[SlrR]] {{PubMed|19788541}}, [[SinR]]-[[SlrR]] {{PubMed|20351052}} | * '''Interactions:''' [[SlrA]]-[[SlrR]] {{PubMed|19788541}}, [[SinR]]-[[SlrR]] {{PubMed|20351052}} | ||
| Line 123: | Line 123: | ||
=References= | =References= | ||
| − | <pubmed>18430133,18647168, 19767430, 19788541 </pubmed> | + | <pubmed>18430133,18647168, 19767430, 19788541 20351052 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 13:36, 31 March 2010
- Description: transcriptional activator of competence development and sporulation genes, represses SigD-dependent flagellar genes, antagonist of SlrA and SinR
| Gene name | slrR |
| Synonyms | yveJ, slr |
| Essential | no |
| Product | transcription regulator, SlrA antagonist |
| Function | regulation of initiation of biofilm formation and of autolysis |
| Regulation of this protein in SubtiPathways: Biofilm | |
| MW, pI | 17 kDa, 9.63 |
| Gene length, protein length | 456 bp, 152 aa |
| Immediate neighbours | epsA, pnbA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU34380
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: binding and concomintant inactivation of SlrA results in release of SinR from the SinR-SrlA complex and subsequent induction of SinR-controlled genes and operons for biofilm formation PubMed, repression of transcription of lytA-lytB-lytC and lytF PubMed
- Protein family:
- Paralogous protein(s): SinR
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: interaction with SinR triggers binding of SlrR to the promoters of lytA-lytB-lytC and lytF, resulting in their repression PubMed
- Localization:
Database entries
- Structure:
- UniProt: P71049
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
