Difference between revisions of "MurF"
(→Database entries) |
|||
Line 99: | Line 99: | ||
* '''Operon:''' | * '''Operon:''' | ||
− | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigM]] {{PubMed|18179421}} |
* '''Regulation:''' | * '''Regulation:''' | ||
Line 127: | Line 127: | ||
=References= | =References= | ||
− | <pubmed>18063720,, </pubmed> | + | <pubmed>18063720, 18179421, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Revision as of 11:25, 19 February 2010
- Description: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase
Gene name | murF |
Synonyms | ydbQ |
Essential | yes PubMed |
Product | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso- 2,6- diaminopimeloyl-D-alanyl-D-alanine synthetase |
Function | peptidoglycan precursor biosynthesis |
Metabolic function and regulation of this protein in SubtiPathways: Cell wall | |
MW, pI | 49 kDa, 5.337 |
Gene length, protein length | 1371 bp, 457 aa |
Immediate neighbours | ddl, cshA |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU04570
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine (according to Swiss-Prot)
- Protein family: murCDEF family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P96613
- KEGG entry: [2]
- E.C. number: 6.3.2.10
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421]
[WorldCat.org]
[DOI]
(P p)
Jean van Heijenoort
Lipid intermediates in the biosynthesis of bacterial peptidoglycan.
Microbiol Mol Biol Rev: 2007, 71(4);620-35
[PubMed:18063720]
[WorldCat.org]
[DOI]
(P p)