Difference between revisions of "AcpS"

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=The gene=
 
=The gene=

Revision as of 15:00, 16 February 2010

  • Description: acyl-carrier protein synthase, 4'-phosphopantetheine transferases

Gene name acpS
Synonyms ydcB
Essential yes PubMed
Product acyl-carrier protein synthase
Function fatty acid biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis
MW, pI 13 kDa, 9.915
Gene length, protein length 363 bp, 121 aa
Immediate neighbours ydcA, ydcC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AcpS context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU04620

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein] (according to Swiss-Prot)
  • Protein family: AcpS family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): magnesium PubMed
  • Effectors of protein activity:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)

Original Publications