Difference between revisions of "SrfAB"
| Line 97: | Line 97: | ||
** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed] | ** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed] | ||
** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}} | ** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}} | ||
| + | ** expressed at high cell density ([[ComA]]) {{PubMed|16091051}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed] | ** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed] | ||
| − | ** [[ComA]]: transcription activation {{PubMed|1715856}} | + | ** [[ComA]]: transcription activation {{PubMed|1715856,16091051}} |
** [[PerR]]: transcription activation {{PubMed|16166527}} | ** [[PerR]]: transcription activation {{PubMed|16166527}} | ||
** [[Spx]]: transcription repression {{PubMed|12642660}} | ** [[Spx]]: transcription repression {{PubMed|12642660}} | ||
| Line 127: | Line 128: | ||
=References= | =References= | ||
| − | <pubmed>17227471,16166527,8288534,10960106, 12642660,8830686,18763711 17218307, 17190806 1715856 </pubmed> | + | <pubmed>17227471,16166527,8288534,10960106, 12642660,8830686,18763711 17218307, 17190806 1715856 16091051</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:47, 15 February 2010
- Description: surfactin synthetase / competence
| Gene name | srfAB |
| Synonyms | comL |
| Essential | no |
| Product | surfactin synthetase / competence |
| Function | antibiotic synthesis |
| MW, pI | 400 kDa, 4.903 |
| Gene length, protein length | 10761 bp, 3587 aa |
| Immediate neighbours | srfAA, comS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU03490
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylation on Ser-999 AND Ser-2045 PubMed
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: membrane PubMed
Database entries
- Structure:
- UniProt: Q04747
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
