Difference between revisions of "SrfAB"

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** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
 
** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
 
** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}}  
 
** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}}  
 +
** expressed at high cell density ([[ComA]]) {{PubMed|16091051}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
 
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
** [[ComA]]: transcription activation {{PubMed|1715856}}  
+
** [[ComA]]: transcription activation {{PubMed|1715856,16091051}}  
 
** [[PerR]]: transcription activation {{PubMed|16166527}}
 
** [[PerR]]: transcription activation {{PubMed|16166527}}
 
** [[Spx]]: transcription repression {{PubMed|12642660}}
 
** [[Spx]]: transcription repression {{PubMed|12642660}}
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=References=
 
=References=
  
<pubmed>17227471,16166527,8288534,10960106, 12642660,8830686,18763711 17218307, 17190806 1715856 </pubmed>
+
<pubmed>17227471,16166527,8288534,10960106, 12642660,8830686,18763711 17218307, 17190806 1715856 16091051</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:47, 15 February 2010

  • Description: surfactin synthetase / competence

Gene name srfAB
Synonyms comL
Essential no
Product surfactin synthetase / competence
Function antibiotic synthesis
MW, pI 400 kDa, 4.903
Gene length, protein length 10761 bp, 3587 aa
Immediate neighbours srfAA, comS
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SrfAB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU03490

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Ser-999 AND Ser-2045 PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: membrane PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • repressed during hydrogen peroxide stress (PerR) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:


Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References