Difference between revisions of "UreA"
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=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[ureA]]-[[ureB]]-[[ureC]]'' {{PubMed|9287005}} | ||
| − | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9287005}}, [[SigH]] {{PubMed|9287005}} | |
| − | |||
| − | * '''[[Sigma factor]]:''' [[SigA]], [[SigH]] | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** | + | ** induced by nitrogen limitation ([[GlnR]], [[TnrA]]) {{PubMed|9287005}} |
** induced in the presence of purine nucleotides (inducer: allantoin) ([[PucR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12374841 PubMed] | ** induced in the presence of purine nucleotides (inducer: allantoin) ([[PucR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12374841 PubMed] | ||
| − | ** repressed during growth in the presence of branched chain amino acids ([[CodY]]) | + | ** repressed during growth in the presence of branched chain amino acids ([[CodY]]) {{PubMed|9287005,12618455}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[GlnR]]: transcription repression | + | ** [[GlnR]]: transcription repression {{PubMed|9287005}} |
| − | ** [[TnrA]]: transcription activation | + | ** [[TnrA]]: transcription activation {{PubMed|9287005}} |
** [[PucR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/12374841 PubMed] | ** [[PucR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/12374841 PubMed] | ||
| − | ** [[CodY]]: transcription repression | + | ** [[CodY]]: transcription repression {{PubMed|9287005,12618455}} |
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 19:19, 2 February 2010
- Description: urease (gamma subunit)
| Gene name | ureA |
| Synonyms | |
| Essential | no |
| Product | urease (gamma subunit) |
| Function | utilization of urea as alternative nitrogen source |
| Metabolic function and regulation of this protein in SubtiPathways: Purine catabolism, Ammonium/ glutamate | |
| MW, pI | 11 kDa, 4.98 |
| Gene length, protein length | 315 bp, 105 aa |
| Immediate neighbours | ureB, csbD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU36660
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Urea + H2O = CO2 + 2 NH3 (according to Swiss-Prot)
- Protein family: urease gamma subunit family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P75030
- KEGG entry: [3]
- E.C. number: 3.5.1.5
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
