Difference between revisions of "Fra"

From SubtiWiki
Jump to: navigation, search
Line 1: Line 1:
* '''Description:''' unknown <br/><br/>
+
* '''Description:''' frataxin-like protein, required for the biosynthesis of iron-sulfur clusters <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
Line 10: Line 10:
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
+
|style="background:#ABCDEF;" align="center"| '''Product''' || frataxin-like protein
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
+
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of iron-sulfur clusters
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 5.377   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 5.377   
Line 66: Line 66:
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''Cofactor(s):''' Fe(2+) is bound with high affinity {{PubMed|20087498}}
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:'''
+
* '''Interactions:''' the protein is active as a dimer {{PubMed|20087498}}, ([[YdhG]])2-[[IscU]], requires iron {{PubMed|20087498}}
  
 
* '''Localization:'''
 
* '''Localization:'''
Line 117: Line 117:
  
 
=References=
 
=References=
 
+
<pubmed> 20087498 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 09:25, 21 January 2010

  • Description: frataxin-like protein, required for the biosynthesis of iron-sulfur clusters

Gene name ydhG
Synonyms
Essential no
Product frataxin-like protein
Function biosynthesis of iron-sulfur clusters
MW, pI 14 kDa, 5.377
Gene length, protein length 369 bp, 123 aa
Immediate neighbours phoB, ydhH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YdhG context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU05750

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): Fe(2+) is bound with high affinity PubMed
  • Effectors of protein activity:
  • Localization:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Wenbin Qi, J A Cowan
A structural and functional homolog supports a general role for frataxin in cellular iron chemistry.
Chem Commun (Camb): 2010, 46(5);719-21
[PubMed:20087498] [WorldCat.org] [DOI] (I p)