Difference between revisions of "HisA"
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=Expression and regulation= | =Expression and regulation= | ||
| − | + | * '''Operon:''' ''[[hisZ]]-[[hisG]]-[[hisD]]-[[hisB]]-[[hisH]]-[[hisA]]-[[hisF]]-[[hisI]]'' {{PubMed|12107147}} | |
| − | * '''Operon:''' | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| − | * '''Regulation:''' repressed by casamino acids | + | * '''Regulation:''' repressed by casamino acids {{PubMed|12107147}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 11:55, 30 December 2009
- Description: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF
| Gene name | hisA |
| Synonyms | |
| Essential | no |
| Product | phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF |
| Function | biosynthesis of histidine |
| Metabolic function and regulation of this protein in SubtiPathways: His | |
| MW, pI | 26 kDa, 4.842 |
| Gene length, protein length | 735 bp, 245 aa |
| Immediate neighbours | hisF, hisH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU34880
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide (according to Swiss-Prot)
- Protein family: hisA/hisF family (according to Swiss-Prot)
- Paralogous protein(s): HisF
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O35006
- KEGG entry: [2]
- E.C. number: 5.3.1.16
Additional information
Expression and regulation
- Regulation: repressed by casamino acids PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
