Difference between revisions of "GlpF"

From SubtiWiki
Jump to: navigation, search
(Expression and regulation)
Line 91: Line 91:
 
=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:''' ''[[glpF]]-[[glpK]]''
+
* '''Operon:''' ''[[glpF]]-[[glpK]]'' {{PubMed|2127799}}
  
 
* '''[[Sigma factor]]:''' [[SigA]]
 
* '''[[Sigma factor]]:''' [[SigA]]
  
* '''Regulation:''' repressed by glucose (8-fold) ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed],  carbon catabolite repression, induction by glycerol
+
* '''Regulation:'''  
 +
** repressed by glucose (8-fold) ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed]  
 +
** induction by glycerol ([[GlpP]])
  
* '''Regulatory mechanism:''' [[CcpA]]: transcription repression,  catabolite repression: repression by [[CcpA]], induction: [[GlpP]]-dependent RNA switch (transcriptional antitermination)
+
* '''Regulatory mechanism:'''  
 +
** [[CcpA]]: transcription repression  
 +
** [[GlpP]]-dependent [[RNA switch]] (transcriptional antitermination)
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 18:44, 4 September 2009

  • Description: glycerol facilitator

Gene name glpF
Synonyms
Essential no
Product glycerol facilitator
Function glycerol uptake
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 28 kDa, 9.506
Gene length, protein length 822 bp, 274 aa
Immediate neighbours glpP, glpK
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GlpF context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU09280

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: View classification (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (8-fold) (CcpA) PubMed
    • induction by glycerol (GlpP)
  • Regulatory mechanism:
    • CcpA: transcription repression
    • GlpP-dependent RNA switch (transcriptional antitermination)
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References