Difference between revisions of "CodY"

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(Extended information on the protein)
(References)
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=References=
 
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<pubmed>19542274, 17493123, 18641142,19202088, 16995897,17982469,18083814, 17993518,9287005, 12618455,, 11331605,17218307 19500589 12591885 19202088 12618455 15802253 11331605 15228537 8793880 15937175 15916605 15916606, </pubmed>
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<pubmed>19542274,17493123,18641142,19202088,16995897,17982469,18083814,17993518,9287005,12618455,11331605,17218307,19500589,12591885,19202088,12618455,15802253,11331605,15228537,8793880,15937175,15916605,15916606,11331605,15228537</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 12:35, 12 August 2009

  • Description: regulation of a large regulon in response to branched-chain amino acid limitation

Gene name codY
Synonyms
Essential no
Product transcriptional pleiotropic repressor
Function regulation of a large regulon in response to

branched-chain amino acid limitation

to the presence of branched-chain amino acids

MW, pI 28 kDa, 4.75
Gene length, protein length 777 bp, 259 aa
Immediate neighbours clpY, flgB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CodY context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU16170

Phenotypes of a mutant

No swarming motility on B medium. PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: codY family (according to Swiss-Prot)
  • Paralogous protein(s):

Genes/ operons controlled by CodY

Extended information on the protein

  • Kinetic information:
  • Domains: contains a GAF domain (ligand binding domain)
  • Modification: phosphorylation on Ser-215 PubMed
  • Cofactor(s):
  • Effectors of protein activity: GTP and branched chained amino acids (BCAA) increase the affinity of CodY for its DNA target sequences PubMed
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 2B0L (C-terminal DNA-binding domain), 2GX5 (N-terminal Gaf domain)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

Tony Wilkinson, York University, U.K. homepage

Oscar Kuipers, University of Groningen, The Netherlands Homepage

Your additional remarks

References