FabD

• Description: malonyl CoA-acyl carrier protein transacylase
  
  

Gene name	fabD
Synonyms	ylpE
Essential	yes PubMed
Product	malonyl CoA-acyl carrier protein transacylase
Function	fatty acid biosynthesis
MW, pI	33 kDa, 4.515
Gene length, protein length	951 bp, 317 aa
Immediate neighbours	plsX, fabG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU15900

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein] (according to Swiss-Prot)

• Protein family: fabD family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P71019

• KEGG entry: [3]

• E.C. number: 2.3.1.39

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • repressed unless the cells experience a lack of malonyl-CoA (FapR) PubMed

• Regulatory mechanism:
  • FapR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Gustavo E Schujman, Luciana Paoletti, Alan D Grossman, Diego de Mendoza
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis.
Dev Cell: 2003, 4(5);663-72
[PubMed:12737802] [WorldCat.org] [DOI] (P p)