Rny

• Description: Rny catalyzes the hydrolysis of both 2',3'-cyclic AMP and 2',3'-cyclic GMP into 3'-AMP and 3'-GMP and is a putative RNase
  
  

Gene name	rny
Synonyms	ymdA
Essential	yes
Product	2',3'-cyclic-nucleotide 2'-phosphodiesterase
Function	hydrolysis of AMP and GMP& putative RNase
MW, pI	58,7 kDa, 5.39
Gene length, protein length	1560 bp, 520 amino acids
Immediate neighbours	pdbX, ymdB
Gene sequence (+200bp)	Protein sequence
Genetic context File:GenE context.gif

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry:

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 3'-phosphate

• Protein family: 2',3' cyclic nucleotide phosphodiesterase family

• Paralogous protein(s): similar to unknown proteins

Extended information on the protein

• Kinetic information:

• Domains:
  • transmembrane domain (4–24)
  • KH domain (210–273)
  • HD domain (336–429)

• Modification:

• Cofactor(s): metal-dependent

• Effectors of protein activity:

• Interactions:

• Localization: Single-pass membrane protein

Database entries

• Structure:

• Swiss prot entry: [2]

• KEGG entry: [3]

• E.C. number: [4]

Additional information

required for processing of gapA operon mRNA

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Labs working on this gene/protein

Jörg Stülke, University of Göttingen, Germany Homepage

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed