GabP

• Description: gamma-amino butyric acid permease
  
  

Gene name	gabP
Synonyms	nrg-21
Essential	no
Product	gamma-amino butyric acid permease
Function	utilization of gamma-amino butyric acid
Metabolic function and regulation of this protein in SubtiPathways: Ala, Gly, Ser
MW, pI	50 kDa, 9.45
Gene length, protein length	1407 bp, 469 aa
Immediate neighbours	cotA, yeaB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU06310

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: View classification (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: P46349

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • expressed in the absence of good nitrogen sources (glutamine or ammonium) (TnrA) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • TnrA: transcription activation PubMed
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

A E Ferson, L V Wray, S H Fisher
Expression of the Bacillus subtilis gabP gene is regulated independently in response to nitrogen and amino acid availability.
Mol Microbiol: 1996, 22(4);693-701
[PubMed:8951816] [WorldCat.org] [DOI] (P p)

1. Brechtel CE, King SC. (1998) 4-Aminobutyrate (GABA) transporters from the amine-polyamine-choline superfamily: substrate specificity and ligand recognition profile of the 4-aminobutyrate permease from Bacillus subtilis. Biochem J. Aug 1;333 ( Pt 3): 565-71. PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed