Difference between revisions of "LiaI"

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* '''Regulation:''' repressed by glucose (4.3-fold) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed],  induced by bacitracin ([[LiaR]])
 
* '''Regulation:''' repressed by glucose (4.3-fold) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed],  induced by bacitracin ([[LiaR]])
 +
** repressed during logrithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed]
  
 
* '''Regulatory mechanism:''' [[LiaR]]: transcription activation
 
* '''Regulatory mechanism:''' [[LiaR]]: transcription activation
 +
** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed]
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 16:13, 11 June 2009

  • Description: maybe involved in resistance to bacitracin

Gene name liaI
Synonyms yvqI
Essential no
Product unknown
Function unknown
MW, pI 13 kDa, 9.303
Gene length, protein length 378 bp, 126 aa
Immediate neighbours liaH, yvqJ
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvqI context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU33130

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: repressed by glucose (4.3-fold) PubMed, induced by bacitracin (LiaR)
  • Regulatory mechanism: LiaR: transcription activation
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Thorsten Mascher, Karlsruhe Institute of Technology, Germany link

Your additional remarks

References

Sina Jordan, Anja Junker, John D Helmann, Thorsten Mascher
Regulation of LiaRS-dependent gene expression in bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system.
J Bacteriol: 2006, 188(14);5153-66
[PubMed:16816187] [WorldCat.org] [DOI] (P p)

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135] [WorldCat.org] [DOI] (P p)

  1. Blencke et al. (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng. 5: 133-149 PubMed
  2. Jordan, S., A. Junker, J. D. Helmann, and T. Mascher. 2006. Regulation of LiaRS-dependent gene expression in Bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system. J. Bacteriol. 188: 5153-5166. PubMed
  3. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed