Difference between revisions of "YbcT"

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(YbcT moved to SkfD over redirect)
 
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#REDIRECT [[SkfD]]
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* '''Description:''' sublancin 168 lantibiotic antimicrobial precursor peptide <br/><br/>
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{| align="right" border="1" cellpadding="2"
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|-
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|style="background:#ABCDEF;" align="center"|'''Gene name'''
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|''sunA''
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|-
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yolG ''
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|-
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no
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|-
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|style="background:#ABCDEF;" align="center"| '''Product''' || sublancin 168 lantibiotic antimicrobial precursor peptide
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|-
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|style="background:#ABCDEF;" align="center"|'''Function''' || antimicrobial peptide
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|-
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 5 kDa, 7.963 
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|-
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 168 bp, 56 aa
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|-
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sunT]]'', ''[[sunI]]''
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|-
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14066&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|-
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|colspan="2" | '''Genetic context''' <br/> [[Image:sunA_context.gif]]
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<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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|-
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|}
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__TOC__
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<br/><br/>
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=The gene=
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=== Basic information ===
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* '''Locus tag:''' BSU21480
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===Phenotypes of a mutant ===
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=== Database entries ===
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* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sunA.html]
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* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12682]
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=== Additional information===
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=The protein=
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=== Basic information/ Evolution ===
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* '''Catalyzed reaction/ biological activity:'''
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* '''Protein family:''' IPP isomerase type 2 family (according to Swiss-Prot)
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* '''Paralogous protein(s):'''
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=== Extended information on the protein ===
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* '''Kinetic information:'''
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* '''Domains:'''
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* '''Modification:'''
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* '''Cofactor(s):'''
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* '''Effectors of protein activity:'''
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* '''Interactions:'''
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* '''Localization:''' cell membrane (according to Swiss-Prot)
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=== Database entries ===
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* '''Structure:'''
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* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P68577 P68577]
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* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU21480]
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* '''E.C. number:'''
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=== Additional information===
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=Expression and regulation=
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* '''Operon:''' ''sunA''
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* '''[[Sigma factor]]:'''
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* '''Regulation:'''
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** repressed during logrithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17720793 PubMed]
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* '''Regulatory mechanism:''' activated by [[YvrHb]]  [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed], repressed by [[AbrB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19465659 PubMed], activated by [[Abh]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19465659 PubMed]
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** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]
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** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]
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** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]
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** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]
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** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/17720793 PubMed]
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* '''Additional information:'''  the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
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=Biological materials =
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* '''Mutant:'''
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* '''Expression vector:'''
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* '''lacZ fusion:'''
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* '''GFP fusion:'''
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* '''two-hybrid system:'''
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* '''Antibody:'''
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=Labs working on this gene/protein=
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=Your additional remarks=
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=References=
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<pubmed>16306698, 19465659  </pubmed>
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# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]

Revision as of 11:37, 11 June 2009

  • Description: sublancin 168 lantibiotic antimicrobial precursor peptide

Gene name sunA
Synonyms yolG
Essential no
Product sublancin 168 lantibiotic antimicrobial precursor peptide
Function antimicrobial peptide
MW, pI 5 kDa, 7.963
Gene length, protein length 168 bp, 56 aa
Immediate neighbours sunT, sunI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SunA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU21480

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: IPP isomerase type 2 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: sunA
  • Regulation:
  • Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Yun Luo, John D Helmann
Extracytoplasmic function sigma factors with overlapping promoter specificity regulate sublancin production in Bacillus subtilis.
J Bacteriol: 2009, 191(15);4951-8
[PubMed:19465659] [WorldCat.org] [DOI] (I p)

Masakuni Serizawa, Keisuke Kodama, Hiroki Yamamoto, Kazuo Kobayashi, Naotake Ogasawara, Junichi Sekiguchi
Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses.
Biosci Biotechnol Biochem: 2005, 69(11);2155-69
[PubMed:16306698] [WorldCat.org] [DOI] (P p)


  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
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