IolI

• Description: inosose isomerase, converts 2KMI to 1-keto-D-chiro-inositol
  
  

Gene name	iolI
Synonyms	yxdH
Essential	no
Product	inosose isomerase, converts 2KMI to 1-keto-D-chiro-inositol
Function	myo-inositol catabolism
MW, pI	31 kDa, 4.661
Gene length, protein length	834 bp, 278 aa
Immediate neighbours	iolJ, iolH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2,4,6/3,5-pentahydroxycyclohexanone = 2,3,5/4,6-pentahydroxycyclohexanone (according to Swiss-Prot)

• Protein family: iolI family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1L60

• Swiss prot entry: P42419

• KEGG entry: BSU39680

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: repressed by glucose (CcpA)

• Regulatory mechanism: CcpA: transcription repression

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y. (2008) myo-Inositol catabolism in Bacillus subtilis. J Biol Chem. Apr 18;283(16): 10415-24. PubMed