Difference between revisions of "MurAA"
| Line 82: | Line 82: | ||
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P70965 P70965] | * '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P70965 P70965] | ||
| − | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU36760] | + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU36760 BSU36760] |
* '''E.C. number:''' [http://www.expasy.org/enzyme/2.5.1.7 2.5.1.7] | * '''E.C. number:''' [http://www.expasy.org/enzyme/2.5.1.7 2.5.1.7] | ||
Revision as of 23:25, 13 May 2009
- Description: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
| Gene name | murAA |
| Synonyms | murA |
| Essential | yes PubMed |
| Product | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
| Function | peptidoglycan precursor biosynthesis |
| MW, pI | 46 kDa, 5.45 |
| Gene length, protein length | 1308 bp, 436 aa |
| Immediate neighbours | spoIID, ywmB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- Swiss prot entry: P70965
- KEGG entry: BSU36760
- E.C. number: 2.5.1.7
Additional information
- subject to Clp-dependent proteolysis upon glucose starvation PubMed
MurAA is subject to ClpC-ClpP-dependent degradation PubMed
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Gerth et al. (2008) Clp-dependent proteolysis down-regulates central metabolic pathways in glucose-starved Bacillus subtilis. J Bacteriol 190:321-331 PubMed
- Kock H, Gerth U, Hecker M. (2004) MurAA, catalysing the first committed step in peptidoglycan biosynthesis, is a target of Clp-dependent proteolysis in Bacillus subtilis. Mol Microbiol, 51:1087-1102. PubMed
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
