Difference between revisions of "FtsH"

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(Phenotypes of a mutant)
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* '''Description:''' write here <br/><br/>
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* '''Description:''' ATP-dependent metalloprotease <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || cell-division protein and general stress protein (class III heat-shock) (EC 3.4.24.-)
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|style="background:#ABCDEF;" align="center"| '''Product''' || ATP-dependent metalloprotease
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || involved in major cellular processes such as sporulation, stress adaptation and secretion
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|style="background:#ABCDEF;" align="center"|'''Function''' || cell division, sporulation initiation
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 70 kDa, 5.841   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 70 kDa, 5.841   

Revision as of 11:54, 7 April 2009

  • Description: ATP-dependent metalloprotease

Gene name ftsH
Synonyms
Essential no
Product ATP-dependent metalloprotease
Function cell division, sporulation initiation
MW, pI 70 kDa, 5.841
Gene length, protein length 1911 bp, 637 aa
Immediate neighbours hprT, coaX
Gene sequence (+200bp) Protein sequence
Genetic context
FtsH context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

strongly reduced sporulation frequency

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: degrades Spo0E, resulting in reduced sporulation frequency in a ftsH mutant
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: membrane PubMed

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Hahne et al. (2008) From complementarity to comprehensiveness - targeting the membrane proteome of growing Bacillus subtilis by divergent approaches. Proteomics 8: 4123-4136 PubMed
  2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed