Difference between revisions of "Sda"
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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− | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || developmental checkpoint protein |
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|style="background:#ABCDEF;" align="center"|'''Function''' || mediates a developmental checkpoint coupling initiation of | |style="background:#ABCDEF;" align="center"|'''Function''' || mediates a developmental checkpoint coupling initiation of |
Revision as of 14:02, 13 March 2009
- Description: Sda is a checkpoint protein that is upregulated in response to replication stress (Burkholder et al 2001, Cell). Sda inhibits the autokinase activity of KinA (and likely KinB as well). This in its turn results in reduced levels of Spo0A~P. Thus, replication stressed cells will not iniate sporulation
Sda is rapidly turned over by the ClpP/X system because of some uncharged residues at its C-terminus Ruvolo et al 2006, MolMic.
Gene name | sda |
Synonyms | |
Essential | no |
Product | developmental checkpoint protein |
Function | mediates a developmental checkpoint coupling initiation of
sporulation (phosphorylation of Spo0A) to the function of replication initiation proteins |
MW, pI | 6 kDa, 5.605 |
Gene length, protein length | 156 bp, 52 aa |
Immediate neighbours | yloV, sdaAA |
Gene sequence (+200bp) | Protein sequence |
Genetic context |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry:
- KEGG entry:
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed