BceB

• Description: ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine, sensory component of the Bce regulatory & detoxification system
  
  

Gene name	bceB
Synonyms	ytsD
Essential	no
Product	bacitracin ABC transporter (permease)
Function	export of toxic peptides
Gene expression levels in SubtiExpress: bceB
Interactions involving this protein in SubtInteract: BceB
MW, pI	72 kDa, 9.79
Gene length, protein length	1938 bp, 646 aa
Immediate neighbours	yttA, bceA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

BceR regulon

The gene

Basic information

• Locus tag: BSU30370

Database entries

• BsubCyc: BSU30370

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • binds bacitracin, K_D: 60 nM PubMed
  • inhibits BceS autophosphorylation activity in the absence of bacitracin PubMed

• Protein family: ABC-4 integral membrane protein family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:
  • the activity of the BceA-BceB ABC transporter is inhibited by heptaprenyl pyrophosphate which accumulates in a ytpB mutant PubMed

• Interactions:
  • BceA-BceB PubMed
  • BceB-BceS, in the absence of bacitracin PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU30370

• Structure:

• UniProt: O34741

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: bceA-bceB PubMed

• Expression browser: bceB PubMed

• Sigma factor:

• Regulation:
  • induced in the presence of bacitracin, plectasin, mersacidin and actagardine (BceR) PubMed

• Regulatory mechanism:
  • BceR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: