Difference between revisions of "Main Page"

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<big>'''Paper of the month: December 2014'''</big>  
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<big>'''Paper of the month: January 2015'''</big>  
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* [[Cell division]] is facilitated by a molecular machine - the [[divisome]] - that assembles at mid-cell in dividing cells. The formation of the cytokinetic Z-ring by [[FtsZ]] is regulated by several factors, including the [[divisome]] component [[EzrA]]. [http://www.ncbi.nlm.nih.gov/pubmed/25403286 Cleverley et al.] now describe the structure of the cytoplasmic domain of [[EzrA]] which comprises five linear repeats of an unusual triple helical bundle. The [[EzrA]] structure is bent into a semicircle, providing the protein with the potential to interact at both N- and C-termini with adjacent membrane-bound [[divisome]] components. The individual repeats, and their linear organization, are homologous to the spectrin proteins that connect actin filaments to the membrane in eukaryotes, and [[EzrA]] is proposed to be the founding member of the bacterial spectrin family.  
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* Proteases are crucial for the maintenance of protein integrity, but also for controlling the cellular levels of specific proteins. For the LonA protease, it has so far been unknown how the protease can specifically target a selected protein as degradation target. Now, [http://www.ncbi.nlm.nih.gov/pubmed/25538299 Mukherjee et al.] form the lab of [[Daniel Kearns]] have studied the degradation of [[SwrA]], a master regulator of flagellar biosynthesis by [[LonA]]. They found that the adaptor protein [[SmiA]] is required for the productive degradation of [[SwrA]] by [[LonA]]. This regulatory mechanism is important to prevent hyperflagellation in liquid media.
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* '''Relevant ''Subti''Wiki pages:''' [[EzrA]], [[FtsZ]], [[divisome]], [[cell division]], [[Rick Lewis]]
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* '''Relevant ''Subti''Wiki pages:''' [[LonA]], [[SwrA]], [[SmiA]], [[proteolysis]], [[Daniel Kearns]]
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<pubmed> 25403286 </pubmed>
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<pubmed> 25538299 </pubmed>
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* [[Previous papers of the month]]
 
* [[Previous papers of the month]]
  

Revision as of 08:14, 12 January 2015

Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

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Contact: General Microbiology, University of Göttingen, send mail


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Now online: A new description of SubtiWiki and its acompanying modules in the 2014 Database issue of Nucleic Acids Research

Raphael H Michna, Fabian M Commichau, Dominik Tödter, Christopher P Zschiedrich, Jörg Stülke
SubtiWiki-a database for the model organism Bacillus subtilis that links pathway, interaction and expression information.
Nucleic Acids Res: 2014, 42(Database issue);D692-8
[PubMed:24178028] [WorldCat.org] [DOI] (I p)



Paper of the month: January 2015

  • Proteases are crucial for the maintenance of protein integrity, but also for controlling the cellular levels of specific proteins. For the LonA protease, it has so far been unknown how the protease can specifically target a selected protein as degradation target. Now, Mukherjee et al. form the lab of Daniel Kearns have studied the degradation of SwrA, a master regulator of flagellar biosynthesis by LonA. They found that the adaptor protein SmiA is required for the productive degradation of SwrA by LonA. This regulatory mechanism is important to prevent hyperflagellation in liquid media.
  • Relevant SubtiWiki pages: LonA, SwrA, SmiA, proteolysis, Daniel Kearns

Sampriti Mukherjee, Anna C Bree, Jing Liu, Joyce E Patrick, Peter Chien, Daniel B Kearns
Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation.
Proc Natl Acad Sci U S A: 2015, 112(1);250-5
[PubMed:25538299] [WorldCat.org] [DOI] (I p)


New procedure for account creation:

  • Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
  • Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!



News in SubtiWiki:

  • August 2014: The first mobile application for SubtiWiki is now available for users of Android phones: Go for SubtiWiki in Google Play! IPhone users, please be patient! You will be served next! Click here to install!
  • April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
  • March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
  • October 2012: the essential genes have been categorized
  • September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
  • August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
  • April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
  • April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
  • December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways



Genes (examples) Additional pages
spo0A SubtiPathways
glnA SubtInteract
rny SubtiExpress
psdA Regulons
pckA methods
dnaA metabolism
rnpA categories
sigB genome-wide analyses
ptkA list of plasmids
mreC labs working on Bacillus
ccpA the people behind SubtiWiki
sr1 template


Publications describing SubtiWiki and SubtiPathways:







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