rplU

168

ribosomal protein bL21

Locus: BSU_27960

Molecular weight: 11.14 kDa

Isoelectric point: 10.16

Protein length: 102 aa

Gene length: 309 bp

Function: translation

Product: ribosomal protein L21 (bL21)

Essential: yes

Synonyms: rplU

Genomic Context

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Categories containing this gene/protein

Information processing, Protein synthesis, modification and degradation, Translation, Ribosomal proteins

Groups of genes, Essential genes

List of homologs in different organisms, belongs to COG0261 (Galperin et al., 2021)

This gene is a member of the following regulons

Stringent response

Gene

Coordinates: 2,855,518  2,855,826

Phenotypes of a mutant

essential PubMed

The protein

Protein family

bacterial ribosomal protein bL21 family (single member, according to UniProt)

Structure

3J9W (PDB) (the ribosome) PubMed
P26908 (AlphaFold)

Additional information

this ribosomal protein is lacking in some organisms with very small genomes PubMed

Expression and Regulation

Operons

Genes: rplU-prp-rpmA

Description: PubMed

Regulation

Rel dependent downregulation (Class I) during stringent response PubMed
likely autorepression of the rplU→rpmA operon expression upon binding of excess of one ribosomal protein to the untranslated region of the rplU→rpmA mRNA PubMed

Regulatory mechanism

stringent response: negative regulation, in stringent response

Genes: spoIVFA-spoIVFB-rplU-prp-rpmA

Description: PubMed

Regulation

expressed early during sporulation in the mother cell (SigE, SpoIIID) PubMed

Additional information

the domains that inhibits SpoIVFB is cleaved off by CtpB (second cleavage) PubMed

Additional information

expression is reduced in motile cells as compared to non-motile cells PubMed

References

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