Difference between revisions of "EzrA"

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(Original Publications)
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
 +
** inhibits [[FtsZ]] polymerization {{PubMed|25403286}}
 +
** recruits [[PBP1|ponA]] to the division septum {{PubMed|25403286}}
  
 
* '''Protein family:''' ezrA family (according to Swiss-Prot)
 
* '''Protein family:''' ezrA family (according to Swiss-Prot)
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* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
 
** [[EzrA]]-[[UgtP]] {{PubMed|17662947}}
 
** [[EzrA]]-[[UgtP]] {{PubMed|17662947}}
** [[FtsZ]]-[[EzrA]] {{PubMed|10449747}}
+
** [[FtsZ]]-[[EzrA]] {{PubMed|25403286,10449747}}
 
** [[EzrA]]-[[GpsB]] {{PubMed|18363795}}
 
** [[EzrA]]-[[GpsB]] {{PubMed|18363795}}
 
** [[EzrA]]-[[PonA]] {{PubMed|18363795}}
 
** [[EzrA]]-[[PonA]] {{PubMed|18363795}}
  
* '''[[Localization]]:''' membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]
+
* '''[[Localization]]:'''  
** 1 transmembrane domain at the N-terminus according to SOSUI
+
** membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]
 +
** 1 transmembrane domain at the N-terminus {{PubMed|25403286}}
  
 
=== Database entries ===
 
=== Database entries ===
 
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU29610&redirect=T BSU29610]
 
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU29610&redirect=T BSU29610]
  
* '''Structure:'''
+
* '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=4uxv 4UXV] (the 60 kDa cytoplasmic domain) {{PubMed|25403286}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O34894 O34894]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O34894 O34894]
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<pubmed> 19680248  19884039 </pubmed>
 
<pubmed> 19680248  19884039 </pubmed>
 
==Original Publications==
 
==Original Publications==
<pubmed>10449747,16420366,15317782,16549676,17662947,12368265,18363795,9387221 15317798 , 19429628, 18763711 21401734 24222488 23701187 17718511 24218584 24097947 24825009 25068683 </pubmed>
+
<pubmed>10449747,16420366,15317782,16549676,17662947,12368265,18363795,9387221 15317798 , 19429628, 18763711 21401734 24222488 23701187 17718511 24218584 24097947 24825009 25068683 25403286 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 09:19, 19 November 2014

  • Description: negative regulator of FtsZ ring formation

Gene name ezrA
Synonyms ytwP
Essential no
Product FtsZ-interacting protein
Function control of FtsZ ring formation
Gene expression levels in SubtiExpress: ezrA
Interactions involving this protein in SubtInteract: EzrA
MW, pI 64 kDa, 4.757
Gene length, protein length 1686 bp, 562 aa
Immediate neighbours braB, hisJ
Sequences Protein DNA DNA_with_flanks
Genetic context
EzrA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
EzrA expression.png















Categories containing this gene/protein

cell division, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29610

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ezrA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 4UXV (the 60 kDa cytoplasmic domain) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • constitutively expressed PubMed
  • Regulatory mechanism:
  • Additional information:
    • degradation of EzrA involves FtsH PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 125 PubMed
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 495 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications