Difference between revisions of "YciC"
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* '''Operon:''' | * '''Operon:''' | ||
− | ** ''[[ | + | ** ''[[folE2]]-[[yciB]]-[[yciC]]'' {{PubMed|9811636}} |
** ''yciC'' {{PubMed|12426338}} | ** ''yciC'' {{PubMed|12426338}} | ||
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* '''Sigma factor:''' | * '''Sigma factor:''' | ||
− | ** ''[[ | + | ** ''[[folE2]]'':[[SigA]] {{PubMed|12426338}} |
** ''[[yciC]]'':[[SigA]] {{PubMed|12426338}} | ** ''[[yciC]]'':[[SigA]] {{PubMed|12426338}} | ||
* '''Regulation:''' | * '''Regulation:''' | ||
− | ** ''[[ | + | ** ''[[folE2]]'': induced by zinc starvation ([[Zur]]) {{PubMed|12426338}} |
** ''[[yciC]]'': induced by zinc starvation ([[Zur]]) {{PubMed|12426338}} | ** ''[[yciC]]'': induced by zinc starvation ([[Zur]]) {{PubMed|12426338}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
− | ** ''[[ | + | ** ''[[folE2]]'': [[Zur]]: transcription repression in the presence of zinc {{PubMed|12426338}} |
** ''[[yciC]]'': [[Zur]]: transcription repression in the presence of zinc {{PubMed|12426338}} | ** ''[[yciC]]'': [[Zur]]: transcription repression in the presence of zinc {{PubMed|12426338}} | ||
Revision as of 15:50, 6 February 2015
- Description: putative metallochaperone
Gene name | yciC |
Synonyms | |
Essential | no |
Product | putative metallochaperone |
Function | zinc uptake |
Gene expression levels in SubtiExpress: yciC | |
Metabolic function and regulation of this protein in SubtiPathways: yciC | |
MW, pI | 45 kDa, 4.399 |
Gene length, protein length | 1191 bp, 397 aa |
Immediate neighbours | yczL, yckA |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU03360
Phenotypes of a mutant
Database entries
- BsubCyc: BSU03360
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: cobW C-terminal domain (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- phosphorylated on Arg-58 PubMed
- Cofactor(s):
- Effectors of protein activity:
- Localization: membrane associated PubMed
Database entries
- BsubCyc: BSU03360
- Structure:
- UniProt: P94400
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
- number of protein molecules per cell (minimal medium with glucose and ammonium): 448 PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Alexander K W Elsholz, Kürsad Turgay, Stephan Michalik, Bernd Hessling, Katrin Gronau, Dan Oertel, Ulrike Mäder, Jörg Bernhardt, Dörte Becher, Michael Hecker, Ulf Gerth
Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis.
Proc Natl Acad Sci U S A: 2012, 109(19);7451-6
[PubMed:22517742]
[WorldCat.org]
[DOI]
(I p)
Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711]
[WorldCat.org]
[DOI]
(I p)
Scott E Gabriel, Faith Miyagi, Ahmed Gaballa, John D Helmann
Regulation of the Bacillus subtilis yciC gene and insights into the DNA-binding specificity of the zinc-sensing metalloregulator Zur.
J Bacteriol: 2008, 190(10);3482-8
[PubMed:18344368]
[WorldCat.org]
[DOI]
(I p)
Ahmed Gaballa, Tao Wang, Rick W Ye, John D Helmann
Functional analysis of the Bacillus subtilis Zur regulon.
J Bacteriol: 2002, 184(23);6508-14
[PubMed:12426338]
[WorldCat.org]
[DOI]
(P p)
A Gaballa, J D Helmann
Identification of a zinc-specific metalloregulatory protein, Zur, controlling zinc transport operons in Bacillus subtilis.
J Bacteriol: 1998, 180(22);5815-21
[PubMed:9811636]
[WorldCat.org]
[DOI]
(P p)