OxdC

• Description: oxalate decarboxylase
  
  

Gene name	oxdC
Synonyms	yvrK
Essential	no
Product	oxalate decarboxylase
Function	unknown
Gene expression levels in SubtiExpress: oxdC
MW, pI	43 kDa, 5.101
Gene length, protein length	1155 bp, 385 aa
Immediate neighbours	yvrJ, yvrL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

acid stress proteins (controlled by YvrI-YvrHa), phosphoproteins

This gene is a member of the following regulons

YvrI-YvrHa regulon

The gene

Basic information

• Locus tag: BSU33240

Database entries

• BsubCyc: BSU33240

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Oxalate = formate + CO₂ (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s): OxdD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-12 PubMed

• Cofactors:
  • requires two Mn(II) centers for activity PubMed

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU33240

• Structure: 1UW8

• UniProt: O34714

• KEGG entry: [2]

• E.C. number: 4.1.1.2

Expression and regulation

• Operon: oxdC-yvrL PubMed

• Expression browser: oxdC PubMed

• Sigma factor: YvrI-YvrHa PubMed

• Regulation: induced by acidic growth conditions PubMed

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 193 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 4306 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 2602 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 4926 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

References

Reviews

Miia R Mäkelä, Kristiina Hildén, Taina K Lundell
Oxalate decarboxylase: biotechnological update and prevalence of the enzyme in filamentous fungi.
Appl Microbiol Biotechnol: 2010, 87(3);801-14
[PubMed:20464388] [WorldCat.org] [DOI] (I p)