BcrC

• Description: undecaprenyl pyrophosphate phosphatase, produces the carrier lipid for cell wall synthesis, bacitracin resistance
  
  

Gene name	bcrC
Synonyms	ywoA
Essential	no
Product	undecaprenyl pyrophosphate phosphatase
Function	cell wall synthesis, resistance to bacitracin and oxidative stress
Gene expression levels in SubtiExpress: bcrC
Metabolic function and regulation of this protein in SubtiPathways: BcrC
MW, pI	21 kDa, 9.455
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	nrgB, ywnJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, cell envelope stress proteins (controlled by SigM, V, W, X, Y), heat shock proteins, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

SigI regulon, SigM regulon, SigW regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU36530

Phenotypes of a mutant

• increased susceptibility to rare earth elements PubMed

Database entries

• BsubCyc: BSU36530

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • undecaprenyl pyrophosphate --> undecaprenyl phosphate

• Protein family: bcrC/ybjG/ywoA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU36530

• Structure:

• UniProt: P94571

• KEGG entry: [2]

• E.C. number:

Additional information

• there is a second undecaprenyl pyrophosphate phosphatase in B. subtilis, YubB. However, YubB seems to play only a minor role. PubMed

Expression and regulation

• Operon: bcrC

• Expression browser: bcrC PubMed

• Sigma factor: SigM PubMed, SigI PubMed, SigW PubMed, SigX PubMed

• Regulation:
  • expression activated by glucose (3.3 fold) PubMed
  • induced by heat shock (SigI) PubMed
  • induced by bacitracin
  • induced by oxidative stress
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: