GroES

• Description: chaperonin, universally conserved protein
  
  

Gene name	groES
Synonyms
Essential	yes PubMed
Product	chaperonin
Function	protein folding and re-folding
Gene expression levels in SubtiExpress: groES
Interactions involving this protein in SubtInteract: GroES
Metabolic function and regulation of this protein in SubtiPathways: groES
MW, pI	10 kDa, 4.595
Gene length, protein length	282 bp, 94 aa
Immediate neighbours	ydiL, groEL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

chaperones/ protein folding, heat shock proteins, essential genes, universally conserved proteins, most abundant proteins

This gene is a member of the following regulons

HrcA regulon

The gene

Basic information

• Locus tag: BSU06020

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU06020

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: groES chaperonin family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on Ser-36 PubMed

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • GroEL-GroES

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU06020

• Structure:

• UniProt: P28599

• KEGG entry: [3]

• E.C. number:

Additional information

universally conserved protein

Expression and regulation

• Operon: groES-groEL PubMed

• Expression browser: groES PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by heat shock (HrcA) PubMed

• Regulatory mechanism: HrcA: transcription repression PubMed

• Additional information:
  • belongs to the 100 most abundant proteins PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 4303 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 10235 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage