YbaE

• Description: ATP-binding A2 component of ECF transporters
  
  

Gene name	ybaE
Synonyms	ecfA2
Essential	no
Product	ECF transporter (ATP-binding protein)
Function	uptake of micronutrients
Gene expression levels in SubtiExpress: ybaE
Interactions involving this protein in SubtInteract: YbaE
Metabolic function and regulation of this protein in SubtiPathways: YbaE
MW, pI	30 kDa, 5.823
Gene length, protein length	828 bp, 276 aa
Immediate neighbours	ybxA, ybaF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ECF transporter, membrane proteins

The gene

Basic information

• Locus tag: BSU01460

Database entries

• BsubCyc: BSU01460

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: EcfA transporter

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • (YbxA-YbaE)-YbaF PubMed

• Localization: membrane associated (via YbaF) PubMed

Database entries

• BsubCyc: BSU01460

• Structure:
  • 4HUQ (EcfA1-EcfA2-EcfT-FolT complex of Lactobacillus brevis), PubMed

• UniProt: P70970

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: ybaE PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Dirk J Slotboom
Structural and mechanistic insights into prokaryotic energy-coupling factor transporters.
Nat Rev Microbiol: 2014, 12(2);79-87
[PubMed:24362466] [WorldCat.org] [DOI] (I p)

Guus B Erkens, Maria Majsnerowska, Josy ter Beek, Dirk Jan Slotboom
Energy coupling factor-type ABC transporters for vitamin uptake in prokaryotes.
Biochemistry: 2012, 51(22);4390-6
[PubMed:22574898] [WorldCat.org] [DOI] (I p)

Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

Original publications

Ke Xu, Minhua Zhang, Qin Zhao, Fang Yu, Hui Guo, Chengyuan Wang, Fangyuan He, Jianping Ding, Peng Zhang
Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis.
Nature: 2013, 497(7448);268-71
[PubMed:23584589] [WorldCat.org] [DOI] (I p)

Josy ter Beek, Ria H Duurkens, Guus B Erkens, Dirk Jan Slotboom
Quaternary structure and functional unit of energy coupling factor (ECF)-type transporters.
J Biol Chem: 2011, 286(7);5471-5
[PubMed:21135102] [WorldCat.org] [DOI] (I p)