Difference between revisions of "Prs"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU00510&redirect=T BSU00510] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/gcaD-prs-ctc.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/gcaD-prs-ctc.html] | ||
| Line 96: | Line 97: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU00510&redirect=T BSU00510] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1IBS 1IBS] [http://www.rcsb.org/pdb/explore.do?structureId=1DKR 1DKR][http://www.rcsb.org/pdb/explore.do?structureId=1DKU 1DKU] | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1IBS 1IBS] [http://www.rcsb.org/pdb/explore.do?structureId=1DKR 1DKR][http://www.rcsb.org/pdb/explore.do?structureId=1DKU 1DKU] | ||
Revision as of 12:46, 2 April 2014
- Description: phosphoribosylpyrophosphate synthetase, universally conserved protein
| Gene name | prs |
| Synonyms | |
| Essential | yes PubMed |
| Product | phosphoribosylpyrophosphate synthetase |
| Function | phosphoribosylpyrophosphate synthesis (biosynthesis of histidine) |
| Gene expression levels in SubtiExpress: prs | |
| Interactions involving this protein in SubtInteract: Prs | |
| Metabolic function and regulation of this protein in SubtiPathways: prs | |
| MW, pI | 34 kDa, 5.895 |
| Gene length, protein length | 951 bp, 317 aa |
| Immediate neighbours | gcaD, ctc |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, biosynthesis/ acquisition of nucleotides, essential genes, universally conserved proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00510
Phenotypes of a mutant
essential PubMed
Database entries
- BsubCyc: BSU00510
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
- Protein family: ribose-phosphate pyrophosphokinase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- subject to feedback inhibition by two end products of purine biosynthesis, adenosine 5'-diphosphate (ADP) and guanosine 5'-diphosphate (GDP) PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU00510
- UniProt: P14193
- KEGG entry: [3]
- E.C. number: 2.7.6.1
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
