Difference between revisions of "KhtU"
| Line 53: | Line 53: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * increased sensitivity to methylglyoxal {{PubMed|24330391}} | ||
=== Database entries === | === Database entries === | ||
Revision as of 17:35, 14 February 2014
- Description: K+/H+ antiporter for K+ efflux
| Gene name | khtU |
| Synonyms | yhaU |
| Essential | no |
| Product | K+/H+ antiporter for K+ efflux |
| Function | potassium ion efflux |
| Gene expression levels in SubtiExpress: khtU | |
| Interactions involving this protein in SubtInteract: khtU | |
| MW, pI | 43 kDa, 9.293 |
| Gene length, protein length | 1224 bp, 408 aa |
| Immediate neighbours | hemZ, khtT |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU09850
Phenotypes of a mutant
- increased sensitivity to methylglyoxal PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Localization:
- cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O07536
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Pete Chandrangsu, Renata Dusi, Chris J Hamilton, John D Helmann
Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol-dependent and independent pathways.
Mol Microbiol: 2014, 91(4);706-15
[PubMed:24330391]
[WorldCat.org]
[DOI]
(I p)
Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin R Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Peter Lewis, Wolfram Liebermeister, Anika March, Ruben A T Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen K Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Jörg Stülke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten van Dijl, Michael Hecker, Uwe Völker, Philippe Bessières, Philippe Noirot
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Science: 2012, 335(6072);1103-6
[PubMed:22383849]
[WorldCat.org]
[DOI]
(I p)
Makoto Fujisawa, Masahiro Ito, Terry A Krulwich
Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity.
Proc Natl Acad Sci U S A: 2007, 104(33);13289-94
[PubMed:17679694]
[WorldCat.org]
[DOI]
(P p)
Makoto Fujisawa, Yuko Wada, Masahiro Ito
Modulation of the K+ efflux activity of Bacillus subtilis YhaU by YhaT and the C-terminal region of YhaS.
FEMS Microbiol Lett: 2004, 231(2);211-7
[PubMed:14987767]
[WorldCat.org]
[DOI]
(P p)
