YidC2

• Description: Sec-independent membrane protein translocase, required for competence development
  
  

Gene name	yidC2
Synonyms	yqjG, oxaAB
Essential	no
Product	Sec-independent membrane protein translocase
Function	membrane insertion of proteins and protein secretion
MW, pI	30 kDa, 9.903
Gene length, protein length	825 bp, 275 aa
Immediate neighbours	mifM, yqjF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, membrane proteins

This gene is a member of the following regulons

MifM regulon

The gene

Basic information

• Locus tag: BSU23890

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): SpoIIIJ, one of the two proteins has to be present for viability PubMed

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • membrane PubMed

Database entries

• Structure:

• UniProt: P54544

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mifM-yidC2 PubMed

• Expression browser: yidC2 PubMed

• Sigma factor:

• Regulation:
  • repressed by large amounts of SpoIIIJ, induced by small amounts of SpoIIIJ (MifM) PubMed

• Regulatory mechanism:
  • MifM: "attenuation mechanism", an mRNA hairpin of the yqjG transcript unfold upon translation arrest of MifM at decreased SpoIIIJ levels PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Ross E Dalbey, Peng Wang, Jan Maarten van Dijl
Membrane proteases in the bacterial protein secretion and quality control pathway.
Microbiol Mol Biol Rev: 2012, 76(2);311-30
[PubMed:22688815] [WorldCat.org] [DOI] (I p)