Difference between revisions of "CtpB"

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(Basic information/ Evolution)
(Extended information on the protein)
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* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
 +
** forms a dimeric ring {{PubMed|24243021}}
 
** [[CtpB]]-[[SpoIVFA]]  {{PubMed|24243021}}
 
** [[CtpB]]-[[SpoIVFA]]  {{PubMed|24243021}}
  

Revision as of 10:07, 3 December 2013

  • Description: carboxy-terminal processing serine protease, cleaves SpoIVFA, this results in processing of pro-SigK

Gene name ctpB
Synonyms yvjB
Essential no
Product carboxy-terminal processing serine protease,
cleaves SpoIVFA
Function control of SigK activation
Gene expression levels in SubtiExpress: ctpB
Interactions involving this protein in SubtInteract: CtpB
MW, pI 52 kDa, 8.641
Gene length, protein length 1440 bp, 480 aa
Immediate neighbours swrAA/2, ftsX
Sequences Protein DNA DNA_with_flanks
Genetic context
YvjB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CtpB expression.png















Categories containing this gene/protein

proteolysis, sigma factors and their control, sporulation proteins

This gene is a member of the following regulons

SigE regulon, SigG regulon

The gene

Basic information

  • Locus tag: BSU35240

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: PDZ protease PubMed
  • Paralogous protein(s): CtpA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Effectors of protein activity:
    • substrate binding of CtpB induces opening of the PDZ gate and protease activation PubMed
    • CtpB acts in concert with a second signaling protease, SpoIVB PubMed

Database entries

  • Structure:
    • forms a ring-like scaffold with two narrow tunnels for substrate binding PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: ctpB (according to DBTBS)
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References