Difference between revisions of "CopA"
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
** two N-terminal soluble domains, CopAa and CopAb, connected by a short linker | ** two N-terminal soluble domains, CopAa and CopAb, connected by a short linker | ||
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2RML 2RML] ( N-terminal soluble domain) | + | * '''Structure:''' |
| + | ** [http://www.rcsb.org/pdb/explore.do?structureId=2RML 2RML] ( N-terminal soluble domain) | ||
| + | ** [http://www.pdb.org/pdb/explore/explore.do?structureId=4BBJ 4BBJ] (the protein from Legionella pneumophila, 45% identity, 79% similarity) {{PubMed|24317491}} | ||
* '''UniProt:''' [http://www.uniprot.org/uniprot/O32220 O32220] | * '''UniProt:''' [http://www.uniprot.org/uniprot/O32220 O32220] | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=copA_3441121_3443529_-1 copA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=copA_3441121_3443529_-1 copA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigA]] {{PubMed|12779235}} | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12779235}} |
| + | |||
* '''Regulation:''' | * '''Regulation:''' | ||
** induced by copper ([[CsoR]]) {{PubMed|18048925,12779235}} | ** induced by copper ([[CsoR]]) {{PubMed|18048925,12779235}} | ||
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==Original publications== | ==Original publications== | ||
| − | + | <pubmed>19751213 11922674,12590580,14663075,12779235,12644235,18048925,14514665,14711369, 19378562 15212800 20233928 24317491 22531974,22077885</pubmed> | |
| − | <pubmed>19751213 11922674,12590580,14663075,12779235,12644235,18048925,14514665,14711369, 19378562 15212800 20233928 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 13:33, 8 January 2014
- Description: copper-transporting ATPase, resistance to copper
| Gene name | copA |
| Synonyms | yvgX |
| Essential | no |
| Product | copper transporting ATPase |
| Function | copper export, detoxification |
| Gene expression levels in SubtiExpress: copA | |
| Interactions involving this protein in SubtInteract: CopA | |
| Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis | |
| MW, pI | 85 kDa, 5.484 |
| Gene length, protein length | 2409 bp, 803 aa |
| Immediate neighbours | cadA, copZ |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), resistance against toxic metals, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU33500
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + H2O + Cu1+(In) = ADP + phosphate + Cu1+(Out) (according to Swiss-Prot)
- Protein family: Type IB subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- two N-terminal soluble domains, CopAa and CopAb, connected by a short linker
- Modification:
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O32220
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Reviews
Amy C Rosenzweig, José M Argüello
Toward a molecular understanding of metal transport by P(1B)-type ATPases.
Curr Top Membr: 2012, 69;113-36
[PubMed:23046649]
[WorldCat.org]
[DOI]
(I p)
Amie K Boal, Amy C Rosenzweig
Structural biology of copper trafficking.
Chem Rev: 2009, 109(10);4760-79
[PubMed:19824702]
[WorldCat.org]
[DOI]
(I p)
Original publications
