Difference between revisions of "FtsX"

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* '''Description:''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[FtsX]]), required for [[CwlO]] activity and for proper activation of [[Spo0A]] and initiation of [[sporulation]] <br/><br/>
+
* '''Description:''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[FtsX]]), required for [[CwlO]] activity (cell elongation) and for proper activation of [[Spo0A]] and initiation of [[sporulation]] <br/><br/>
  
 
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
* a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed|23855774}}
+
* a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed|23869552,23855774}}
* shorter, fatter cells {{PubMed|23855774}}
+
* shorter, fatter cells, this can be rescued by addition of Mg(2+) {{PubMed|23869552,23855774}}
 +
* reduced growth rate, especially at low Mg(2+) concentrations {{PubMed|23869552}}
  
 
=== Database entries ===
 
=== Database entries ===
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
 
* '''[[SubtInteract|Interactions]]:'''  
 
* '''[[SubtInteract|Interactions]]:'''  
** [[FtsE]]-[[FtsX]] {{PubMed|18573177}}
+
** [[FtsE]]-[[FtsX]] {{PubMed|23869552,18573177}}
 
** [[FloT]]-[[FtsX]] {{PubMed|23651456}}
 
** [[FloT]]-[[FtsX]] {{PubMed|23651456}}
 +
** [[FtsX]]-[[CwlO]], at the membrane {{PubMed|23869552}}
  
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot),  membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]
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* '''[[Localization]]:'''  
 +
** cell membrane {{PubMed|23869552}}
  
 
=== Database entries ===
 
=== Database entries ===
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=References=
 
=References=
  
<pubmed>10092453,18573177,23651456,14651647,18763711, 23855774</pubmed>
+
<pubmed>10092453,18573177,23651456,14651647,18763711, 23855774 23869552</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:35, 14 December 2013

Gene name ftsX
Synonyms
Essential no
Product ABC transporter (membrane protein)
Function control of cell wall synthesis
Gene expression levels in SubtiExpress: ftsX
Interactions involving this protein in SubtInteract: FtsX
MW, pI 32 kDa, 10.016
Gene length, protein length 888 bp, 296 aa
Immediate neighbours ctpB, ftsE
Sequences Protein DNA DNA_with_flanks
Genetic context
FtsX context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FtsX expression.png















Categories containing this gene/protein

ABC transporters, cell wall synthesis, phosphorelay, membrane proteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

  • Locus tag: BSU35250

Phenotypes of a mutant

  • a ftsX mutation is synthetically lethal with a lytE mutation (due to a lack of autolysin activity) PubMed
  • shorter, fatter cells, this can be rescued by addition of Mg(2+) PubMed
  • reduced growth rate, especially at low Mg(2+) concentrations PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • necessary for the autolysin activity of CwlO PubMed
  • Protein family: FtsX subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References