Difference between revisions of "Main Page"

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<big>'''Paper of the month: November 2013'''</big>  
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<big>'''Paper of the month: December 2013'''</big>  
* Cyclic di-AMP is an essential second messenger in ''B. subtilis'' and other Gram-positive bacteria. This molecule has been discovered only in 2008, and a lot of work has recently been devoted to the investigation of its function. This month, [http://www.ncbi.nlm.nih.gov/pubmed/24141192 Nelson et al.] from the lab of [[Ronald Breaker]] discovered that c-di-AMP binds to the [[ydaO riboswitch]]. This is extremely interesting since the molecule does also bind the [[KtrA]] potassium transporter. The ''[[ktrA]]-[[ktrB]]'' operon is also controlled by a [[ydaO riboswitch]]. Thus c-di-AMP is the first signalling nucleotide that controls a biological process by binding both a protein and the encoding mRNA.
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* Intercellular signaling requires the transfer of information between two different cells. Now, [http://www.ncbi.nlm.nih.gov/pubmed/24243021 Mastny et al.] from the labs of [[David Rudner]] and Tim Clausen show how the protease [[CtpB]] is activated by substrate binding to cleave off the inhibitory domain of [[SpoIVFA]] to allow ultimately allow processing of pro-[[SigK]] by [[SpoIVFB]].
* '''Relevant ''Subti''Wiki pages:''' [[Ronald Breaker]], [[ydaO riboswitch]], [[KtrA]], ''[[ydaO]]'', [[metabolism of signalling nucleotides]]
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* '''Relevant ''Subti''Wiki pages:''' [[David Rudner]], [[sporulation]], [[CtpB]], [[SpoIVB]], [[SpoIVFA]], [[SpoIVFB]]
<pubmed> 24141192 </pubmed>
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<pubmed> 24243021 </pubmed>
* Additional papers on c-di-AMP from 2013
 
<pubmed> 23192352 23671116 </pubmed>
 
 
* [[Previous papers of the month]]
 
* [[Previous papers of the month]]
  

Revision as of 10:22, 3 December 2013

Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

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Contact: General Microbiology, University of Göttingen, send mail



Important note: SubtiWiki will not be available from Thursday (November 14) to Monday (November 18) due to server maintenance!



Upcoming events:


New: Subtiwiki is now on Facebook - please give it a +1!



Now online: A new description of SubtiWiki and its acompanying modules in the 2014 Database issue of Nucleic Acids Research

Raphael H Michna, Fabian M Commichau, Dominik Tödter, Christopher P Zschiedrich, Jörg Stülke
SubtiWiki-a database for the model organism Bacillus subtilis that links pathway, interaction and expression information.
Nucleic Acids Res: 2014, 42(Database issue);D692-8
[PubMed:24178028] [WorldCat.org] [DOI] (I p)



Paper of the month: December 2013

Markus Mastny, Alexander Heuck, Robert Kurzbauer, Anja Heiduk, Prisca Boisguerin, Rudolf Volkmer, Michael Ehrmann, Christopher D A Rodrigues, David Z Rudner, Tim Clausen
CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis.
Cell: 2013, 155(3);647-58
[PubMed:24243021] [WorldCat.org] [DOI] (I p)


New procedure for account creation:

  • Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
  • Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!



News in SubtiWiki:

  • April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
  • March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
  • October 2012: the essential genes have been categorized
  • September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
  • August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
  • April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
  • April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
  • December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
  • December 2010: all genes are linked to regulons, and the pages of the regulons provide an overview on all genes that are members of this specific regulon.
  • December 2010: all genes/proteins are linked to categories, and the pages of the categories provide an overview on all genes/proteins that are members of this specific category.


Genes (examples) Additional pages
spo0A SubtiPathways
glnA SubtInteract
rny SubtiExpress
psdA Regulons
pckA methods
dnaA metabolism
rnpA categories
sigB genome-wide analyses
ptkA list of plasmids
mreC labs working on Bacillus
ccpA the people behind SubtiWiki
sr1 template


Publications describing SubtiWiki and SubtiPathways: