YtxJ

• Description: general stress protein
  
  

Gene name	ytxJ
Synonyms	csb40
Essential	no
Product	unknown
Function	unknown
Gene expression levels in SubtiExpress: ytxJ
MW, pI	12 kDa, 5.089
Gene length, protein length	324 bp, 108 aa
Immediate neighbours	aroA, ytxH
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

general stress proteins (controlled by SigB), phosphoproteins

This gene is a member of the following regulons

SigB regulon, SigH regulon

The gene

Basic information

• Locus tag: BSU29760

Database entries

• BsubCyc: BSU29760

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: Trx family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: contains a single conserved Cys residue in a motif (TCPIS) reminiscent of that found in monothiol glutaredoxins [3]

• Modification: phosphorylation on (Thr-93 OR Ser-94 OR Ser-96 OR Thr-99) PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU29760

• Structure:

• UniProt: P39914

• KEGG entry: [4]

• E.C. number:

Expression and regulation

• Operon: ytxG-ytxH-ytxJ PubMed

• Expression browser: ytxJ PubMed

• Sigma factor: SigB PubMed, SigH PubMed

• Regulation:
  • induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Your additional remarks

YpdA, YqiW, YphP and YtxJ cooccur in those species predicted to synthesize bacillithiol.

References

Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541] [WorldCat.org] [DOI] (I p)

Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)

D Varón, M S Brody, C W Price
Bacillus subtilis operon under the dual control of the general stress transcription factor sigma B and the sporulation transcription factor sigma H.
Mol Microbiol: 1996, 20(2);339-50
[PubMed:8733232] [WorldCat.org] [DOI] (P p)