Difference between revisions of "RelA"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * requirement for valine {{PubMed|24163341}} | ||
| + | * a ''[[relA]] [[yjbM]] [[ywaC]]'' triple mutant requires branched chain amino acids, methionine and threonine for growth, the requirement can be suppressed by reduced expression of ''[[guaB]]'' or inactivation of ''[[codY]]'' {{PubMed|24163341}} | ||
=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
| + | ** N-terminal ppGpp hydrolase domain {{PubMed|24163341}} | ||
| + | ** central ppGpp synthetase domain {{PubMed|24163341}} | ||
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=relA_2820529_2822733_-1 relA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=relA_2820529_2822733_-1 relA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
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=References= | =References= | ||
| − | + | <pubmed>11948165,9383190,10209741,13129942,, 19447912 13129942 12372825 12081964 11948165 12419222 23028324 24163341</pubmed> | |
| − | <pubmed>11948165,9383190,10209741,13129942,, 19447912 13129942 12372825 12081964 11948165 12419222 23028324 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 11:47, 22 December 2013
- Description: GTP pyrophosphokinase (stringent response)
| Gene name | relA |
| Synonyms | |
| Essential | no |
| Product | GTP pyrophosphokinase |
| Function | synthesis and degradation of (p)ppGpp, triggering the stringent response |
| Gene expression levels in SubtiExpress: relA | |
| Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Nucleotides (regulation), Murein recycling | |
| MW, pI | 84 kDa, 6.964 |
| Gene length, protein length | 2202 bp, 734 aa |
| Immediate neighbours | yrvI, apt |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
metabolism of signalling nucleotides
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU27600
Phenotypes of a mutant
- requirement for valine PubMed
- a relA yjbM ywaC triple mutant requires branched chain amino acids, methionine and threonine for growth, the requirement can be suppressed by reduced expression of guaB or inactivation of codY PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate (according to Swiss-Prot)
- Protein family: relA/spoT family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O54408
- KEGG entry: [3]
- E.C. number: 2.7.6.5
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Mohamed Marahiel, Marburg University, Germany homepage
Your additional remarks
References
