Difference between revisions of "Fnr"

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Revision as of 14:50, 16 May 2013

  • Description: transcriptional regulator of anaerobic genes

Gene name fnr
Synonyms
Essential no
Product transcription regulator (Crp family)
Function regulation of anaerobiosis, fermentation and overflow metabolism
Gene expression levels in SubtiExpress: fnr
Metabolic function and regulation of this protein in SubtiPathways:
Alternative nitrogen sources
MW, pI 27 kDa, 5.989
Gene length, protein length 714 bp, 238 aa
Immediate neighbours ywiC, narK
Sequences Protein DNA DNA_with_flanks
Genetic context
Fnr context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Fnr expression.png















Categories containing this gene/protein

regulators of electron transport, transcription factors and their control

This gene is a member of the following regulons

Fnr regulon, NsrR regulon, ResD regulon

The Fnr regulon

The gene

Basic information

  • Locus tag: BSU37310

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Genes/ operons controlled by Fnr

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: contains an iron-sulfur cluster

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Elisabeth Härtig, Dieter Jahn
Regulation of the anaerobic metabolism in Bacillus subtilis.
Adv Microb Physiol: 2012, 61;195-216
[PubMed:23046954] [WorldCat.org] [DOI] (I p)

The Fnr regulon

Other original publications

Ines Gruner, Claudia Frädrich, Lars H Böttger, Alfred X Trautwein, Dieter Jahn, Elisabeth Härtig
Aspartate 141 is the fourth ligand of the oxygen-sensing [4Fe-4S]2+ cluster of Bacillus subtilis transcriptional regulator Fnr.
J Biol Chem: 2011, 286(3);2017-21
[PubMed:21068385] [WorldCat.org] [DOI] (I p)

Michiko M Nakano, Hao Geng, Shunji Nakano, Kazuo Kobayashi
The nitric oxide-responsive regulator NsrR controls ResDE-dependent gene expression.
J Bacteriol: 2006, 188(16);5878-87
[PubMed:16885456] [WorldCat.org] [DOI] (P p)

M M Nakano, Y Zhu, M Lacelle, X Zhang, F M Hulett
Interaction of ResD with regulatory regions of anaerobically induced genes in Bacillus subtilis.
Mol Microbiol: 2000, 37(5);1198-207
[PubMed:10972836] [WorldCat.org] [DOI] (P p)

M M Nakano, P Zuber, P Glaser, A Danchin, F M Hulett
Two-component regulatory proteins ResD-ResE are required for transcriptional activation of fnr upon oxygen limitation in Bacillus subtilis.
J Bacteriol: 1996, 178(13);3796-802
[PubMed:8682783] [WorldCat.org] [DOI] (P p)

H Cruz Ramos, L Boursier, I Moszer, F Kunst, A Danchin, P Glaser
Anaerobic transcription activation in Bacillus subtilis: identification of distinct FNR-dependent and -independent regulatory mechanisms.
EMBO J: 1995, 14(23);5984-94
[PubMed:8846791] [WorldCat.org] [DOI] (P p)