TuaD

• Description: UDP glucose 6-dehydrogenase
  
  

Gene name	tuaD
Synonyms	yvhD
Essential	no
Product	UDP glucose 6-dehydrogenase
Function	biosynthesis of teichuronic acid
Gene expression levels in SubtiExpress: tuaD
Interactions involving this protein in SubtInteract: TuaD
MW, pI	49 kDa, 6.107
Gene length, protein length	1383 bp, 461 aa
Immediate neighbours	tuaE, tuaC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components

This gene is a member of the following regulons

PhoP regulon

The gene

Basic information

• Locus tag: BSU35580

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UDP-glucose + 2 NAD⁺ + H₂O = UDP-glucuronate + 2 NADH (according to Swiss-Prot)

• Protein family: UDP-glucose/GDP-mannose dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): YtcA, Ugd

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on a Tyr residue by PtkA PubMed, dephosphorylated by PtpZ PubMed

• Cofactor(s):

• Effectors of protein activity: PtkA-dependent phosphorylation stimulates TuaD activity PubMed

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O32271

• KEGG entry: [3]

• E.C. number: 1.1.1.22

Expression and regulation

• Operon: tuaA-tuaB-tuaC-tuaD-tuaE-tuaF-tuaG-tuaH PubMed

• Expression browser: tuaD PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions of phosphate limitation (PhoP) PubMed

• Regulatory mechanism:
  • PhoP: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: