YodB

• Description: MarR/DUF24 family transcription repressor of azoR1, catD-catE and yodC expression
  
  

Gene name	yodB
Synonyms
Essential	no
Product	MarR/DUF24 family transcription repressor
Function	regulation of quinone and diamide detoxification
Gene expression levels in SubtiExpress: yodB
MW, pI	12 kDa, 4.737
Gene length, protein length	336 bp, 112 aa
Immediate neighbours	yodA, yodC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

YodB regulon

The YodB regulon:

• azoR1, catD-catE, yodB, yodC

The gene

Basic information

• Locus tag: BSU19540

Phenotypes of a mutant

• increased resistance to catechol, quinones and diamide PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: MarR/DUF24 family

• Paralogous protein(s): CatR

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: redox-controlled by intersubunit disulfide formation of Cys6 and Cys101' in response to quinones and diamide

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34844

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: yodB PubMed

• Sigma factor:

• Regulation:
  • subject to autorepression PubMed

• Regulatory mechanism:
  • YodB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

References

Reviews

Antelmann H, Helmann JD.
Thiol-based redox switches and gene regulation.
Antioxid Redox Signal. 2011,14:1049-63.
PubMed

Haike Antelmann, Michael Hecker, Peter Zuber
Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.
Expert Rev Proteomics: 2008, 5(1);77-90
[PubMed:18282125] [WorldCat.org] [DOI] (I p)

Original Publications

Bui Khanh Chi, Katrin Gronau, Ulrike Mäder, Bernd Hessling, Dörte Becher, Haike Antelmann
S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics.
Mol Cell Proteomics: 2011, 10(11);M111.009506
[PubMed:21749987] [WorldCat.org] [DOI] (I p)

Bui Khanh Chi, Dirk Albrecht, Katrin Gronau, Dörte Becher, Michael Hecker, Haike Antelmann
The redox-sensing regulator YodB senses quinones and diamide via a thiol-disulfide switch in Bacillus subtilis.
Proteomics: 2010, 10(17);3155-64
[PubMed:20652907] [WorldCat.org] [DOI] (I p)

Bui Khanh Chi, Kazuo Kobayashi, Dirk Albrecht, Michael Hecker, Haike Antelmann
The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis.
J Bacteriol: 2010, 192(18);4571-81
[PubMed:20639328] [WorldCat.org] [DOI] (I p)

Montira Leelakriangsak, Nguyen Thi Thu Huyen, Stefanie Töwe, Nguyen van Duy, Dörte Becher, Michael Hecker, Haike Antelmann, Peter Zuber
Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis.
Mol Microbiol: 2008, 67(5);1108-24
[PubMed:18208493] [WorldCat.org] [DOI] (I p)

Van Duy Nguyen, Carmen Wolf, Ulrike Mäder, Michael Lalk, Peter Langer, Ulrike Lindequist, Michael Hecker, Haike Antelmann
Transcriptome and proteome analyses in response to 2-methylhydroquinone and 6-brom-2-vinyl-chroman-4-on reveal different degradation systems involved in the catabolism of aromatic compounds in Bacillus subtilis.
Proteomics: 2007, 7(9);1391-408
[PubMed:17407181] [WorldCat.org] [DOI] (P p)

Montira Leelakriangsak, Kazuo Kobayashi, Peter Zuber
Dual negative control of spx transcription initiation from the P3 promoter by repressors PerR and YodB in Bacillus subtilis.
J Bacteriol: 2007, 189(5);1736-44
[PubMed:17158660] [WorldCat.org] [DOI] (P p)