Difference between revisions of "MurD"
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| − | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=murD_1588901_1590256_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:murD_expression.png|500px]] | + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=murD_1588901_1590256_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:murD_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15200]] |
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Revision as of 13:14, 16 May 2013
- Description: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
| Gene name | murD |
| Synonyms | |
| Essential | yes PubMed |
| Product | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase |
| Function | peptidoglycan precursor biosynthesis |
| Gene expression levels in SubtiExpress: murD | |
| Metabolic function and regulation of this protein in SubtiPathways: Cell wall | |
| MW, pI | 49 kDa, 5.566 |
| Gene length, protein length | 1353 bp, 451 aa |
| Immediate neighbours | mraY, spoVE |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of cell wall components, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU15200
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (according to Swiss-Prot)
- Protein family: murCDEF family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: Q03522
- KEGG entry: [3]
- E.C. number: 6.3.2.9
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- expressed during vegatative growth PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Jean van Heijenoort
Lipid intermediates in the biosynthesis of bacterial peptidoglycan.
Microbiol Mol Biol Rev: 2007, 71(4);620-35
[PubMed:18063720]
[WorldCat.org]
[DOI]
(P p)
R A Daniel, J Errington
DNA sequence of the murE-murD region of Bacillus subtilis 168.
J Gen Microbiol: 1993, 139(2);361-70
[PubMed:8436954]
[WorldCat.org]
[DOI]
(P p)
A O Henriques, H de Lencastre, P J Piggot
A Bacillus subtilis morphogene cluster that includes spoVE is homologous to the mra region of Escherichia coli.
Biochimie: 1992, 74(7-8);735-48
[PubMed:1391053]
[WorldCat.org]
[DOI]
(P p)
