Difference between revisions of "Ddl"

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Revision as of 12:35, 16 May 2013

  • Description: D-alanine-D-alanine ligase

Gene name ddl
Synonyms ddlA
Essential yes PubMed
Product D-alanine-D-alanine ligase
Function peptidoglycan precursor biosynthesis
Gene expression levels in SubtiExpress: ddl
Metabolic function and regulation of this protein in SubtiPathways:
Cell wall
MW, pI 38 kDa, 4.58
Gene length, protein length 1062 bp, 354 aa
Immediate neighbours ydbP, murF
Sequences Protein DNA DNA_with_flanks
Genetic context
Ddl context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Ddl expression.png




























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

  • Locus tag: BSU04560

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine (according to Swiss-Prot)
  • Protein family: ATP-grasp domain (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2YZG (from Thermus thermophilus hb8 mutant, 40% identity, 53% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421] [WorldCat.org] [DOI] (P p)