YwjE

• Description: minor cardiolipin synthetase
  
  

Gene name	ywjE
Synonyms	clsB
Essential	no
Product	minor cardiolipin synthetase
Function	phospholipid biosynthesis
Gene expression levels in SubtiExpress: ywjE
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	45 kDa, 9.053
Gene length, protein length	1194 bp, 398 aa
Immediate neighbours	fadF, ywjD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, sporulation proteins, membrane proteins

The gene

Basic information

• Locus tag: BSU37190

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: Cardiolipin synthase subfamily (according to Swiss-Prot)

• Paralogous protein(s): ClsA, YwiE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P45865

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ywjE-ywjD PubMed

• Expression browser: ywjE PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • there is an antisense transcript for ywjE (as-ywjE) PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin R Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Peter Lewis, Wolfram Liebermeister, Anika March, Ruben A T Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen K Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Jörg Stülke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten van Dijl, Michael Hecker, Uwe Völker, Philippe Bessières, Philippe Noirot
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Science: 2012, 335(6072);1103-6
[PubMed:22383849] [WorldCat.org] [DOI] (I p)

Letal I Salzberg, John D Helmann
Phenotypic and transcriptomic characterization of Bacillus subtilis mutants with grossly altered membrane composition.
J Bacteriol: 2008, 190(23);7797-807
[PubMed:18820022] [WorldCat.org] [DOI] (I p)

Claudia S López, Alejandro F Alice, Horacio Heras, Emilio A Rivas, Carmen Sánchez-Rivas
Role of anionic phospholipids in the adaptation of Bacillus subtilis to high salinity.
Microbiology (Reading): 2006, 152(Pt 3);605-616
[PubMed:16514141] [WorldCat.org] [DOI] (P p)

Fumitaka Kawai, Momoko Shoda, Rie Harashima, Yoshito Sadaie, Hiroshi Hara, Kouji Matsumoto
Cardiolipin domains in Bacillus subtilis marburg membranes.
J Bacteriol: 2004, 186(5);1475-83
[PubMed:14973018] [WorldCat.org] [DOI] (P p)