MdtR

• Description: transcription repressor of the multidrug-resistance mdtR-mdtP operon
  
  

Gene name	mdtR
Synonyms	yusO
Essential	no
Product	transcription repressor (MarR family)
Function	regulation of the multidrug-resistance mdtR-mdtP operon
Gene expression levels in SubtiExpress: mdtR
MW, pI	17 kDa, 6.376
Gene length, protein length	465 bp, 155 aa
Immediate neighbours	yusN, mdtP
Sequences	Protein DNA DNA_with_flanks
Genetic context

Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

MdtR regulon

The MdtR regulon:

• mdtR-mdtP

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1S3J

• UniProt: O32181

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: mdtR-mdtP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism: repression by MdtR PubMed

• Additional information:

Biological materials

• Mutant: GP1115 (spc), available in Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ji-Yun Kim, Takashi Inaoka, Kazutaka Hirooka, Hiroshi Matsuoka, Makiko Murata, Reiko Ohki, Yoshikazu Adachi, Yasutaro Fujita, Kozo Ochi
Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.
J Bacteriol: 2009, 191(10);3273-81
[PubMed:19286808] [WorldCat.org] [DOI] (I p)