NucB

• Description: sporulation-specific extracellular nuclease
  
  

Gene name	nucB
Synonyms
Essential	no
Product	sporulation-specific extracellular nuclease
Function	DNA degradation after mother cell lysis
Gene expression levels in SubtiExpress: nucB
MW, pI	14 kDa, 5.173
Gene length, protein length	408 bp, 136 aa
Immediate neighbours	yqeB, spoIVCB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of nucleotides, membrane proteins

This gene is a member of the following regulons

SigE regulon

The gene

Basic information

• Locus tag: BSU25750

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P42983

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: nucB PubMed

• Expression browser: nucB PubMed

• Sigma factor: SigE PubMed

• Regulation: expressed during sporulation (SigE) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Shigeo Hosoya, Zuolei Lu, Yousuke Ozaki, Michio Takeuchi, Tsutomu Sato
Cytological analysis of the mother cell death process during sporulation in Bacillus subtilis.
J Bacteriol: 2007, 189(6);2561-5
[PubMed:17209033] [WorldCat.org] [DOI] (P p)

D van Sinderen, R Kiewiet, G Venema
Differential expression of two closely related deoxyribonuclease genes, nucA and nucB, in Bacillus subtilis.
Mol Microbiol: 1995, 15(2);213-23
[PubMed:7746143] [WorldCat.org] [DOI] (P p)