Difference between revisions of "Ogt"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[kinE]]'', ''[[mtnA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[kinE]]'', ''[[mtnA]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13540 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13540 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13540 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13540 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13540 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13540 DNA_with_flanks]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:ogt_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ogt_context.gif]]

Revision as of 10:02, 14 May 2013

  • Description: O6-methylguanine DNA alkyltransferase

Gene name ogt
Synonyms dat
Essential no
Product O6-methylguanine DNA alkyltransferase
Function DNA repair
Gene expression levels in SubtiExpress: ogt
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 18 kDa, 7.092
Gene length, protein length 495 bp, 165 aa
Immediate neighbours kinE, mtnA
Sequences Protein DNA DNA_with_flanks
Genetic context
Ogt context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Ogt expression.png




























Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU13540

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine (according to Swiss-Prot)
  • Protein family: MGMT family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1SFE (from E. coli, 36% identity, 51% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References